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. 2020 Dec 10;7:527. doi: 10.3389/fvets.2020.00527

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Copyright © 2020 Souza, de Carvalho, Candido, de Mendonça, Fernanda da Silva, Parreira, Dias, Ambrósio, Arantes, da Silva Filho, Nascimento, Costa, Sairre, Veneziani and Magalhães.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Liver (A) and spleen (B) parasite load of L. (L.) infantum-infected hamsters treated intraperitoneal with 20 and 50 mg/kg of body weight of LicoA (1) during eight consecutive days 4 weeks after infection. Thirty-five days after treatment the animals were sacrificed and the parasite burden was evaluated both in spleen and liver by limiting dilution method. Negative control group received the same number of injections of phosphate buffered saline (PBS) and animals from positive control group was treated with meglumine antimoniate (MA) (Glucantime®-Sanofi-Aventis) at dose 50 mg/kg of body. An asterisk indicates statistically significant differences as compared to the negative control group (PBS) (*p < 0.05, **p < 0.01).