Table 1.
Leishmanicidal activity and mammalian cytotoxicity of LicoA and its analogs.
| Compounds | IC50-μMa (95% CI)bL (L.) amazonensis | IC50-μMa (95% CI)bL (L.) infantum | CC50-μMc (95% CI)b Peritoneal murine macrophages | ||||
|---|---|---|---|---|---|---|---|
| Promastigote | Amastigote | Promastigote | Amastigote | ||||
| 24 h | 48 h | 48 h | 24 h | 48 h | 48 h | 48 h | |
| LicoA (1) | 20.26 (17.26–24.54) |
3.88 (2.84–4.89) |
36.84 (32.25–40.02) |
41.10 (37.55–44.98) | 12.47 (10.02–15.06) |
29.58 (26.03–33.06) |
123.10 (119.87–128.65) |
| LLA1 (1a) | 74.94 (71.39–78.42.) |
67.16 (62.66–71.74) |
nd | nd | nd | nd | >400 |
| LLA2 (2a) | 300.6 (297.05–304.08) |
287.26 (283.71–290.74) |
nd | nd | nd | nd | >400 |
| AmpB | 0.27 (0.19–0.42) |
0.065 (0.054–0.078) |
0.022 (0.018–0.026) | nd | nd | nd | 21.90 (18.23–26.87) |
| MA | nd | nd | nd | >400 | >400 | >400 | >400 |
a
IC50, 50% Inhibitory Concentration;
b
95% CI, Confidence interval;
c
CC50: 50% Cytotoxic Concentration; nd, no determined; AmpB, amphotericin B; MA, meglumine antimoniate.