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. 2020 Dec 10;10:576362. doi: 10.3389/fonc.2020.576362

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Copyright © 2020 Castro-Piedras, Vartak, Sharma, Pandey, Casas, Molehin, Rasha, Fokar, Nichols, Almodovar, Rahman and Pruitt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MeCP2 depletion induces transcriptional changes in MDA-MB-468 cells. (A) A volcano plot showing up-regulated (red) and down-regulated genes (blue) in RNA-Seq analysis between NTC and sh1 MeCP2 (upper panel) and NTC vs sh3 MeCP2 (bottom panel). (B) Venn diagram representing overlap of MeCP2 ChIP-Seq peaks and RNA-Seq analysis in MDA-MB-468 cells. (C) Differential expression of 20 selected genes of the 175 genes common in MDA-MB-468 ChIP-Seq and RNA-Seq. (D) Role of selected genes in cancer tumorigenesis.