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. 2020 Dec 10;10:576362. doi: 10.3389/fonc.2020.576362

Figure 4.

Figure 4

Endogenous MeCP2 is acetylated at key lysine residues. (A) The table indicates putative lysine residues that were found to be acetylated on MeCP2 under basal condition (DMSO) and upon deacetylase inhibition using 2 µM panobinostat (PANO), 10 µM SIRT1/2 Inhibitor-IV (IV), 10 µM SIRT1/2 Inhibitor-VII (VII), and 10 µM pracinostat (PRAC) and showed ion peaks at mass/charge (m/z) ratio of ∼126 in PC3 and MDA-MB-468 cells. (B) Approximate representation of the position of acetylated lysine (K) residues on MeCP2 conserved domain is shown. N, N-terminal; MBD, Methyl-binding-domain: A-T Hook domain: TRD, Transcriptional repression domain: His-rich, Histidine-rich domain: Pro-rich, Proline-rich domain, C, C-terminal.