Table 4.
Pathway analysis of the intersecting genes of MeCP2 ChIP-Seq and RNA-Seq.
| Pathway identifier | Pathway name | Genes |
|---|---|---|
| R-HSA-9612973 | Autophagy | RRAGD |
| R-HSA-1640170 | Cell Cycle | DMGDH;MECP2;DACH1;PIM1;L1CAM;PHLDA1 |
| R-HSA-8953897 | Cellular responses to external stimuli | DMGDH;DACH1;NCF1;RRAGD;ADRA1B;CRYAB |
| R-HSA-1266738 | Developmental Biology | DMGDH;NRP2;ADGRV1;PLXND1;SEMA3E;IRS2;L1CAM;MECP2;DACH1;COL4A1;ITGA10;COL5A2;PI3;KRTAP3-1;EPHA2 |
| R-HSA-1643685 | Disease | JAG2;DMGDH;PDGFRA;FLII;PCDH8;IRS2;ISG15;FMO3;L1CAM;MECP2;NT5E;DACH1;TBXAS1;PIM1;GPC2;LRAT;GGT1;TMEM45A;MUC6 |
| R-HSA-73894 | DNA Repair | TNNT2;ISG15 |
| R-HSA-1474244 | Extracellular matrix organization | MECP2;MMP25;COL4A1;ITGB4;COL7A1;ITGA10;COL5A2;P3H2;LTBP1 |
| R-HSA-74160 | Gene expression (Transcription) | DMGDH;MECP2;GRIN2A;DACH1;CAV1;IGFBP3;RRAGD;PCDH8;NALCN;ANKRD6 |
| R-HSA-109582 | Hemostasis | PDGFRA;CAV1;TFPI2;L1CAM;F3;PSG9;CEACAM3;PSG8;ISLR;PSG5;PSG4;ITGA10;HABP4;TIMP3;SLC16A8;KIF1A;RAPGEF3;CD177 |
| R-HSA-168256 | Immune System | DMGDH;NCF1;MAST4;ITGB4;FBXO27;IRS2;CST6;MECP2;C4B;MMP25;DACH1;PIM1;SNCG;PI3;MUC6;CD177;PDGFRA;OSBPL6;IL34;LIF;ISG15;OLFM4;CEACAM3;BST2;RAPGEF3 |
| R-HSA-1430728 | Metabolism | ARL9;DMGDH;CLIC5;NRP2;MOGAT2;WNK4;LTBP1;NALCN;NT5E;DACH1;GPC2;LRAT;ST3GAL6;SLC16A8;GGT1;UGT1A7;GGT2;OSBPL6;CAV1;CYP4B1;FMO3;KMO;TIAM2;AKR1B10;TBXAS1;RAPGEF3 |
| R-HSA-392499 | Metabolism of proteins | DMGDH;OSBPL6;NCF1;FBXO27;IGFBP3;PCDH8;P3H2;LTBP1;NALCN;ZDBF2;MECP2;NT5E;LGALS1;DACH1;COL4A1;COL7A1;TNNT2;ATP13A4;CPE;ST3GAL6;FOLR1;TMEM45A;MUC6;RABL6 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | RABL6 |
| R-HSA-9609507 | Protein localization | P3H2 |
| R-HSA-162582 | Signal Transduction | DMGDH;CLIC5;NRP2;NCF1;PLXND1;FLII;STK39;IRS2;GRIK2;ADRA1B;NALCN;MECP2;NT5E;DACH1;GPC2;LRAT;ST3GAL6;NTSR1;JAG2;PDGFRA;EDN1;CAV2;PDE6G;CAV1;GPR55;L1CAM;F3;TIAM2;FOSL1;AKR1B10;COL4A1;COL5A2;PPP1R1B;RRAGD;RAPGEF3;RABL6 |
| R-HSA-382551 | Transport of small molecules | DMGDH;SLC15A1;DACH1;TTYH1;ATP10D;WNK4;ATP13A4;ATP13A5;SLC16A8;SLC12A7;NALCN |
| R-HSA-5653656 | Vesicle-mediated transport | TBC1D2;MAST4;COL4A1;COL7A1;P3H2;HSF4;KIF1A;FOLR1;KIAA0319;RABL6 |