Table 2.
Ventilatory and biological parameters at the time of ECMO implantation, under ECMO and after ECMO weaning.
| At the time of ECMO implantation | Under ECMO | After ECMO weaning | p-value | |
|---|---|---|---|---|
| Ventilatory parameters | ||||
| Tidal volume (mL/kg of predicted body weight) | 6.1 [4.0–6.3] | 3.4 [2.5–3.6]$ | 5.8 [5.2–6.6]£ | <0.0001 |
| Respiratory rate (/min) | 25 [22–32] | 14 [12–16]$ | 33 [31–34]£ | <0.0001 |
| Total PEEP (cmH2O) | 14 [13–18] | 18 [17–20]$ | 10 [10–14]*,$ | <0.0001 |
| FiO2 (%) | 100 [73–100] | 60 [46–60]$ | 42 [35–50]* | <0.001 |
| Plateau pressure (cmH2O) | 29 [28–32] | 26 [25–28]$ | 28 [27–30] | 0.02 |
| Driving pressure (cmH2O) | 15 [10–19] | 8 [7–11]$ | 16 [13–20]£ | 0.001 |
| Compliance of respiratory system (mL/cmH2O) | 20 [18–34] | 27 [19–32] | 23 [19–27] | 0.92 |
| Mechanical power (J/min) | 25 [17–42] | 6 [2–8]$ | 29 [27–34]£ | <0.0001 |
| Oxygenation index | 28 [26–35] | 13 [10–15]$ | 9 [7–11]* | <0.0001 |
| Biological parameters | ||||
| PaO2/FiO2 ratio | 68 [58–89] | 168 [137–218]$ | 185 [165–257]* | <0.0001 |
| PaCO2 (mmHg) | 58 [48–70] | 44 [41–48]$ | 54 [48–60]£ | 0.02 |
| Lactate (mmol/L) | 1.6 [1.4–2.1] | 1.8 [1.1–2.3] | 1.1 [0.9–1.4]*,$ | 0.03 |
| pH | 7.35 [7.29–7.37] | 7.44 [7.33–7.47]$ | 7.38 [7.32–7.40]£ | 0.04 |
n = 11. Data are expressed as median [interquartile range].
P-value for Friedman test.
*
p < 0.05 after ECMO weaning vs. at the time of ECMO implantation.
£
p < 0.05 after ECMO weaning vs. under ECMO.
$
p < 0.05 under ECMO vs. at the time of ECMO implantation.
ECMO, extracorporeal membrane oxygenation; PEEP, positive end-expiratory pressure; FiO2, inspired fraction of oxygen; PaO2, arterial partial oxygen pressure; PaCO2, arterial partial carbon dioxide pressure.