Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 10;14:601176. doi: 10.3389/fncel.2020.601176

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Kaminski, Köster, Mouloud, Börger, Felderhoff-Müser, Bendix, Giebel and Herz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

MSC-EVs increase neuronal and vessel densities 1 week after HI. Neuronal (A), vessel (B), and oligodendrocyte (C) densities were analyzed via immunohistochemistry for NeuN, CD31, and Olig2, respectively. Analysis was carried out in stitched large scale confocal images of the striatum obtained from brain sections of 16-day-old C57BL/6 mice that were exposed to HI on postnatal day 9. Vehicle (0.9% NaCl, Veh) and MSC-EVs were administered i.p. 24, 72, and 120 h after HI. White squares in large scale representative images (scale bar: 500 μm) indicate the location of high resolution images (scale bar: 50 μm) shown below. Cellular densities were quantified by unbiased automated software-based object detection. *p < 0.05, n = 12/group.