Table 6.
The within centrality of the extended brain reward system (eBRS) and its constituent brain regions in the controls (CON), relapsers (REL), and abstainers (ABS) at 1 month (TP1) into treatment and at follow-up 3 months later (TP2).
| Within Centrality | |||
|---|---|---|---|
| CON | REL | ABS | |
| eBRS at TP1 | 0.0049 (0.2003) | −0.2436 (0.1778) | 0.0359 (0.2017) |
| eBRS at TP2 | −0.1523 (0.2194) | −0.2391 (0.2397) | 0.1471 (0.1448) |
| Cortical regions of the eBRS at TP1 | 0.1733 (0.1843) | 0.0290 (0.2384) | 0.1341 (0.2176) |
| Cortical regions of the eBRS at TP2 | 0.1473 (0.1743) | 0.1022 (0.2610) | 0.1171 (0.1293) |
| Dorsolateral prefrontal cortex at TP1 | −0.1114 (0.4122) | −0.0794 (0.5655) | −0.3486 (0.5492) |
| Dorsolateral prefrontal cortex at TP2 | −0.1067 (0.4851) | 0.2491 (0.3454) | −0.3347 (0.4669) |
| Ventromedial prefrontal cortex at TP1 | 0.8596 (0.2856) | 0.3953 (0.4138) | 0.8757 (0.3856) |
| Ventromedial prefrontal cortex at TP2 | 0.7934 (0.3303) | 0.5350 (0.4612) | 0.8445 (0.5252) |
| Orbital prefrontal cortex at TP1 | −0.1600 (0.4266) | −0.1255 (0.3833) | −0.4341 (0.4233) |
| Orbital prefrontal cortex at TP2 | −0.3087 (0.3559) | −0.3080 (0.5440) | −0.5214 (0.3037) |
| Anterior insula at TP1 | 0.2710 (0.4351) | 0.0259 (0.5111) | 0.3529 (0.5579) |
| Anterior insula at TP2 | 0.2173 (0.5129) | 0.0805 (0.5947) | 0.2776 (0.3284) |
| Temporal pole at TP1 | 0.0072 (0.4142) | −0.0704 (0.4172) | 0.2247 (0.4153) |
| Temporal pole at TP2 | 0.1414 (0.4298) | −0.0455 (0.3643) | 0.3197 (0.2966) |
| Subcortical regions of the eBRS at TP1 | −0.2054 (0.3359) | −0.5843 (0.2875) | −0.0868 (0.3452) |
| Subcortical regions of the eBRS at TP2 | −0.2185 (0.3901) | −0.6659 (0.3955) | 0.1845 (0.3250) |
| Hippocampus at TP1 | −0.2466 (0.3918) | −0.4128 (0.5059) | −0.1500 (0.5297) |
| Hippocampus at TP2 | −0.2821 (0.3681) | −0.3535 (0.3253) | 0.1320 (0.4208) |
| Amygdala at TP1 | −0.1762 (0.5847) | −0.4825 (0.6132) | −0.1466 (0.5626) |
| Amygdala at TP2 | −0.2966 (0.6699) | −0.4582 (0.7446) | 0.1793 (0.5773) |
| Anterior thalamus at TP1 | −0.3836 (0.6392) | −0.6222 (0.7669) | 0.2164 (0.5956) |
| Anterior thalamus at TP2 | −0.0951 (0.6114) | −0.6823 (0.9323) | −0.0853 (0.5315) |
| Nucleus accumbens at TP1 | −0.0151 (0.5071) | −0.8199 (0.6019) | −0.2672 (0.6515) |
| Nucleus accumbens at TP2 | −0.2003 (0.6036) | −1.1694 (0.6302) | 0.5119 (0.5847) |
The table lists the mean and the standard deviation (in brackets) of the normally distributed group-specific within centrality values at each timepoint. With exception of the dorsolateral prefrontal cortex and the orbital prefrontal cortex, abstainers had generally the highest Within Centrality values of all three groups, whereas relapsers had the smallest Within Centrality values.