Table 3.
Univariate Cox regression analysis of OS, DMFS, and DFS in the primary cohort.
| Variable | OS | DMFS | DFS | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Gender | ||||||
| Male | Reference | Reference | Reference | |||
| Female | 0.701 (0.606 to 0.812) | <0.001 | 0.593 (0.497 to 0.708) | <0.001 | 0.735 (0.650 to 0.830) | <0.001 |
| Age | ||||||
| <40 | Reference | Reference | Reference | |||
| 40–49 | 1.187 (1.011 to 1.394) | 0.036 | 1.090 (0.869 to 1.222) | 0.726 | 1.090 (0.957 to 1.241) | 0.194 |
| 50–59 | 1.534 (1.294 to 1.818) | <0.001 | 1.184 (0.983 to 1.427) | 0.075 | 1.290 (1.120 to 1.485) | <0.001 |
| ≥60 | 2.895 (2.427 to 3.451) | <0.001 | 1.477 (1.187 to 1.837) | <0.001 | 1.994 (1.709 to 2.326) | <0.001 |
| Smoking | ||||||
| no | Reference | Reference | Reference | |||
| yes | 1.396 (1.240 to 1.573) | <0.001 | 1.386 (1.210 to 1.587) | <0.001 | 1.348 (1.218 to 1.491) | <0.001 |
| Drinking | ||||||
| no | Reference | Reference | Reference | |||
| yes | 1.168 (0.993 to 1.373) | 0.061 | 1.233 (1.029 to 1.478) | 0.023 | 1.192 (1.039 to 1.366) | 0.012 |
| Family history of tumor | ||||||
| no | Reference | Reference | Reference | |||
| yes | 0.918 (0.802 to 1.051) | 0.216 | 0.936 (0.803 to 1.092) | 0.402 | 0.913 (0.814 to 1.024) | 0.121 |
| 8th T stage | ||||||
| T1 | Reference | Reference | Reference | |||
| T2 | 1.887 (1.446 to 2.463) | <0.001 | 1.618 (1.222 to 2.141) | <0.001 | 1.835 (1.487 to 2.264) | <0.001 |
| T3 | 2.332 (1.853 to 2.934) | <0.001 | 1.834 (1.444 to 2.331) | <0.001 | 2.001 (1.668 to 2.400) | <0.001 |
| T4 | 4.076 (3.219 to 5.161) | <0.001 | 2.940 (2.291 to 3.773) | <0.001 | 3.299 (2.731 to 3.987) | <0.001 |
| 8th N stage | ||||||
| N0 | Reference | Reference | Reference | |||
| N1 | 1.907 (1.505 to 2.415) | <0.001 | 2.232 (1.655 to 3.010) | <0.001 | 1.791 (1.484 to 2.161) | <0.001 |
| N2 | 3.137 (2.453 to 4.013) | <0.001 | 4.089 (3.010 to 5.555) | <0.001 | 2.692 (2.207 to 3.284) | <0.001 |
| N3 | 4.859 (3.767 to 6.267) | <0.001 | 6.886 (5.040 to 9.408) | <0.001 | 3.922 (3.184 to 4.832) | <0.001 |
| pre-EBV-DNA | ||||||
| <4,000 copies/ml | Reference | Reference | Reference | |||
| ≥4,000 copies/ml | 2.266 (2.004 to 2.561) | <0.001 | 2.694 (2.332 to 3.112) | <0.001 | 2.118 (1.911 to 2.347) | <0.001 |
| pre-HGB | ||||||
| <120 g/L | Reference | Reference | Reference | |||
| ≥120 g/L | 0.778 (0.623 to 0.971) | 0.027 | 0.798 (0.618 to 1.029) | 0.082 | 0.822 (0.678 to 0.997) | 0.046 |
| pre-ALB | ||||||
| <45 g/L | Reference | Reference | Reference | |||
| ≥45 g/L | 0.686 (0.606 to 0.777) | <0.001 | 0.810 (0.705 to 0.930) | 0.003 | 0.809 (0.729 to 0.896) | <0.001 |
| pre-CRP | ||||||
| <2 mg/L | Reference | Reference | Reference | |||
| ≥2 mg/L | 1.526 (1.356 to 1.718) | <0.001 | 1.461 (1.277 to 1.672) | <0.001 | 1.354 (1.226 to 1.497) | <0.001 |
| pre-LDH | ||||||
| <180 U/L | Reference | Reference | Reference | |||
| ≥180 U/L | 1.501 (1.333 to 1.690) | <0.001 | 1.444 (1.261 to 1.654) | <0.001 | 1.381 (1.250 to 1.527) | <0.001 |
| IC | ||||||
| No | Reference | Reference | Reference | |||
| Yes | 1.423 (1.263 to 1.603) | <0.001 | 1.509 (1.316 to 1.730) | <0.001 | 1.408 (1.273 to 1.557) | <0.001 |
| CC | ||||||
| No | Reference | Reference | Reference | |||
| Yes | 1.145 (0.986 to 1.329) | 0.076 | 1.260 (1.057 to 1.503) | 0.01 | 1.156 (1.018 to 1.311) | 0.025 |
CI, confidence interval; HR, hazard ratio.
Cox proportional hazard model was used to conduct Cox regression analysis.