Figure 11.

Characterizations of atherosclerotic lesions in aortic sinuses of Ldlr^−/- mice. (a) Neutral lipids in atherosclerotic lesions were stained with ORO stain. Frozen sections of aortic sinuses were immunostained with antibodies against (b) α-smooth muscle actin of smooth muscle cells, (c) CD107b of activated macrophage, and (d) β2GPI complexed with oxLDL. Hoechst was used as counterstain for nuclei. White arrow insets show migrations of smooth muscle cells from vascular intima to media. Scale bar = 200 μm.