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. 2020 Dec 10;8:599389. doi: 10.3389/fcell.2020.599389

FIGURE 5.

FIGURE 5

The effects of BPN14770 on spatial learning and memory of Scopolamine treated mice in the Morris Water Maze test. (A) Learning curve in the acquisition trials of the Morris Water Maze test from sub-acute treatment of different doses of BPN14770. BPN14770 reversed scopolamine-induced spatial memory deficit 24 h after the acquisition trials. In the probe trials, the latency to platform location (B,C), entries into the target quadrant (D,E) after treatment with BPN14770 and different inhibitors. H89, Sirtinol, and MK-2206 each prevented the effects of 0.03 mg/kg BPN14770. Results are displayed as mean ± S.E.M. (n = 10 per group); ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 vs. vehicle-treated control group; #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. vehicle-treated scopolamine group; $P < 0.05 and $$P < 0.01 vs. BPN-treated scopolamine group. Rol, rolipram; Sco, Scopolamine; Sirt, Sirtinol; and MK, MK-2206.