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. 2020 Dec 10;8:599389. doi: 10.3389/fcell.2020.599389

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Copyright © 2020 Wang, Gao, Zheng, Chen, Ma, Shen, Qu, Zhang, Gurney, O’Donnell and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunoblot analysis for the ratio of Bcl-2 to Bax in the hippocampus. The ratio of Bcl-2 to Bax is decreased after scopolamine treatment, but reversed by 0.01 and 0.03 mg/kg BPN14770 (A). Pre-treatment with H89 (B), sirtinol (C), or MK-2206 (D) prevented the therapeutic effects of BPN14770 on protein expression. Results are displayed as mean ± S.E.M. (n = 4–5 per group). ^∗∗P < 0.01 and ^∗∗∗P < 0.001 vs. vehicle-treated control group; ^##P < 0.01 and ^###P < 0.001 vs. vehicle-treated scopolamine group; ^$$P < 0.01 and ^$$$P < 0.001 vs. BPN-treated scopolamine group. Rol, rolipram; Sirt, sirtinol; and MK, MK-2206.