Table 3.
Sample population distribution and sub-analysis of the influence of advanced parental age on incidence of NSCS sub-types.
| Article | Sample Population Distribution of NSCS Sub-types | Advanced Maternal Age | Prevalence Ratio (OR (95% CI)) | Advanced Paternal Age | Prevalence Ratio (OR (95% CI)) |
|---|---|---|---|---|---|
| Boulet et al. 2008 | 39% sagittal (n = 100) 19% metopic (n = 48) 17% lambdoid (n = 43) 17% coronal (n = 44) 8% multi-sutural (n = 20) |
35–44 | sagittal: 2.32 (1.48, 3.63)a metopic: 2.27 (1.16, 4.45)a lambdoid: 2.08 (1.04, 4.17)a coronal: 1.98 (0.93, 4.24) N/A |
N/A | N/A |
| Lee et al. 2012 | 47% sagittal (n = 246) 21.5% metopic (n = 112) 17.1% coronal (n = 89) 1.3% lambdoid (n = 7) 13% multi-sutural (n = 68) |
40+ | sagittal: 2.01 (0.97, 4.14)a metopic: 3.00 (1.18, 7.63)a coronal: 1.17 (0.28, 4.84) N/A multi-sutural: 1.44 (0.34, 6.02) |
N/A | N/A |
| Singer et al. 1999 | 41.2% sagittal (n = 70) 21.8% lambdoid (n = 37) 15.9% coronal (n = 27) 2.9% metopic (n = 5) 7.0% multi-sutural (n = 12 |
35+ | sagittal: 2.34 (0.91, 5.63) lambdoid: 1.20 (0.33, 4.41) coronal: 1.40 (0.28, 6.89) N/A |
40+ | sagittal: 2.11 (0.89, 5.00)a lambdoid: 5.09 (1.45, 17.85)a coronal: 2.03 (0.39, 10.61)a N/A |
a
Statistically significant.