Table 2.

Frequency of NTRK gene fusions in selected tumor histologies.

Histology	Frequency NTRK gene fusions	95% CI
Secretory breast carcinoma	92.87%	72.62–100.00
Fibrosarcoma, infantile (congenital)	90.56%	67.42–100.00
Secretory salivary gland cancer (also known as mammary analogue secretory carcinoma)	79.68%	62.84–96.51
Pigmented spindle cell nevus of Reed	56.52%	34.49–76.81
Pleomorphic adenoma	50.47%	0.00–100.00
Papillary thyroid carcinoma, pediatric	25.93%	11.11–46.28
Differentiated thyroid cancer, pediatric	22.22%	6.41–47.64
Congenital mesoblastic nephroma (all subsets)	21.52%	13.06–32.20
High grade glioma	21.21%	8.98–38.91
Low grade mucoepidermoid carcinoma	20.00%	5.73–43.66
Acinic cell carcinoma of salivary gland	11.11%	4.19–22.63
Diffuse leptomeningeal glioneuronal tumor	10.00%	2.11–26.53
Frequency of NTRK gene fusions in common tumor types
Cervical carcinoma	0.36%	0.00–0.81
Uterine soft tissue sarcoma	0.34%	0.00–0.78
Cutaneous melanoma	0.31%	0.07–0.55
Pancreatic adenocarcinoma	0.31%	0.09–0.53
Colorectal adenocarcinoma	0.26%	0.15–0.36
Neuroendocrine tumors	0.26%	0.07–0.44
Non-small cell lung cancer	0.17%	0.09–0.25
Invasive breast carcinoma	0.10%	0.03–0.18
Examples of primary brain tumors
High grade glioma	21.21%	8.98–38.91
Diffuse leptomeningeal glioneuronal tumor	10.00%	2.11–26.53
High grade glioma, pediatric	6.19%	3.11–9.28
Glial, glioneuronal, and ependymal	3.28%	0.40–11.35
Dysembryoplastic neuroepithelial tumors, pediatric	3.03%	0.08–15.76
Low grade glioma, pediatric	1.61%	0.00–3.33
Glioma	0.99%	0.00–2.79
Low grade glioma	0.88%	0.22–1.54
Glioma/neuroepithelial tumor	0.55%	0.24–1.07

CI, confidence interval.