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. 2020 Dec 22;4:2470547020980681. doi: 10.1177/2470547020980681

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Smaller volumes in the All MDD group compared to the HC group. A and B, After one single infusion of ketamine, All MDD group (including MDD and MDD/PTSD subjects) still showed smaller volume in some regions compared to HC. Additionally, left lateral OFC volume was significantly smaller in the All MDD group 24 h after ketamine administration. Bar represented mean ± SEM. Asterisks indicates significance at p < 0.05. C and D, Colored voxels showing the local volume changes in the All MDD group after ketamine administration (threshold at p < 0.001, FWE corrected). The color bar represents the t-score of Jacobian values. MNI coordinates: x= −14, y = −27, z = 41.Voxels were involved in eight regions, none of which showed significant volume difference compared to HC. IPG: inferior parietal gyrus; MCC: middle cingulate & paracingulate gyri; MOG: middle occipital gyrus; SMG: supramarginal gyrus.