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. 2020 Dec 22;4:2470547020980681. doi: 10.1177/2470547020980681

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Significant improvement of depression and PTSD symptoms in MDD/PTSD subjects. A, The volume of right opercular IFG in MDD/PTSD subjects were slightly increased after ketamine administration, which resulted in the non-significant volume differences compared to HC. B and C, The depression and PTSD severity were significantly alleviated within 24 h and 48 h after ketamine administration. The improvement of PTSD severity was significantly related to the improved HAMD severity in MDD/PTSD subjects.