Fig. 1.

Echocardiographic data showing that activation of merCremer in naïve mice induces transient cardiac dysfunction. (A) The experimental timeline. Adult 10- to 14-week-old wild-type (+/+) mice (n=4), and mice (n=6) expressing a tamoxifen-induced Cre recombinase transgene (+/+;Myh6-merCremer), were injected with tamoxifen (40 mg/kg) on three consecutive days, followed by echocardiographic assessments of cardiac function, including (B) fractional shortening and (C) the myocardial performance index (MPI). Data are means±s.e.m. (in all figures). *P<0.05 versus +/+; ^†P<0.05 versus baseline value (Day 0). Additional echocardiographic parameters are reported in Fig. S1.