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. 2020 Dec 18;13(12):dmm046375. doi: 10.1242/dmm.046375

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — qRT-PCR determinations indicating DNA damage in hearts after tamoxifen-induced activation of merCremer. (A) qRT-PCR assessments showing that Cre activation caused increased expression of a battery of genes encoding markers of DNA damage. Data are presented as fold changes relative to +/+ mice, normalized to Gapdh. The colored lines denote the expression of each gene in +/+;Myh6-merCremer hearts, relative to expression in +/+ wild-type controls at y=1 (dashed line), normalized to Gapdh. (B) Correlated TUNEL determinations. The inset shows a representative 600× TUNEL image; all TUNEL signals were nuclear (verified by DAPI staining). n=3 hearts per time point; *P<0.05 versus +/+.