Fig. 7.

merCremer increases cardiac dysfunction following myocardial infarction (MI). Wild-type (+/+) and +/+;Myh6-merCremer mice were subjected to MI, followed 3 days later by tamoxifen-induced activation of merCremer (40 mg/kg/day×3 days). (A) Indices of left ventricular function [fractional shortening (FS), ejection fraction (EF) and MPI; n=5/group] determined by echocardiography on the indicated days post-MI. Additional echocardiographic parameters are provided in Table S2. (B) Representative trichrome-stained cross-sections (left) obtained at intervals of 0.8 mm along the basal-apical axis of +/+ and +/+;Myh6-merCremer hearts at 28 days post-MI; blue stain denotes the area of the scar. Scar size was quantified (right) by measurement of the area and midline length. *P<0.05 versus +/+; ^†P<0.05 versus baseline value (0 days post-MI).