Fig. 2.

Nuclear pore complex assembly in the mammalian cell cycle. When mammalian cells enter mitosis (M phase), nuclear pore complexes (NPCs) are disassembled into subcomplexes during nuclear envelope (NE) breakdown. These subcomplexes are recycled at the end of mitosis to assemble new NPCs in the reforming nuclear envelope around the genomes of the daughter cells (mitotic NPC assembly). From G1 phase to G2 phase, daughter cells double their number of NPCs in preparation for the next round of cell division (interphase NPC assembly).