Fig. 2.

In vivo measurements in mice treated with either vehicle or S961. (A) Accumulated food intake during the 2-week study was similar in the two groups. (B) The S961 mice lost slightly more weight than the vehicle mice but the difference was only significant at day 14. (C) Oral glucose tolerance test identified significantly increased blood glucose in the S961 group compared to the vehicle group. (D) At day 13, the mean plasma glucose levels were 9.50±0.22 mmol/l in the vehicle group and 20.02±1.48 mmol/l in the S961 group. (E) The mean plasma insulin levels were 1450±96.1 pg/ml in the vehicle group and 34400±884 pg/ml in the S961 group. (F) Total pancreas weight did not differ significantly between the two groups. For statistical analysis, unpaired Student's t-tests were used. ***P<0.001, S961 compared to vehicle. Error bars represent s.e.m.