Table 2. Univariable and Clinicopathologic-Adjusted Multivariable Cox Proportional Hazards Model for RFSa.
| Genomic factor/gene | Data | Univariable analysis | Clinicopathologic-adjusted multivariable analysis | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | FDR-corrected P value | HR (95% CI) | P value | ||
| TMB, median (IQR) | 4.7 (2.5-8.2) | 1.02 (1.01-1.03) | <.001 | NA | 1.01 (1.00-1.03) | .07 |
| FGA ( × 100), median (IQR) | 3.8 (0.4-11.1) | 1.04 (1.02-1.05) | <.001 | NA | 1.03 (1.01-1.04) | .005 |
| Gene, No. (%) | ||||||
| ERBB2 | 20 (5) | 2.94 (1.47-5.88) | .002 | .03 | 1.99 (0.96-4.16) | .07 |
| SMARCA4 | 12 (3) | 3.57 (1.55-8.19) | .003 | .03 | 2.44 (1.03-5.77) | .04 |
| TP53 | 138 (32) | 2.32 (1.53-3.51) | <.001 | .003 | 1.73 (1.09-2.73) | .02 |
Abbreviations: FDR, false discovery rate; FGA, fraction of genome altered; HR, hazard ratio; IQR, interquartile range; NA, not applicable; RFS, relapse-free survival; TMB, normalized tumor mutation burden.
a
Full univariable analysis is presented in eTable 4 in the Supplement.