Table 2.
Odds ratios (95% CI) for outcomes at age 18 per SD increase in polygenic risk score for T2DM or schizophrenia.
| Outcome/risk factor | Sample | OR (95% C.I.) |
p-value | Corrected p-valuec | |
|---|---|---|---|---|---|
| Unadjusteda | Adjusted for sex, ethnicity, social class and BMIb | ||||
| Definite PEs | |||||
| PRS-T2DM | 3768 | 1.15 (0.99–1.34) | 1.21 (1.01–1.45) | 0.027 | 0.054 |
| Psychotic disorder | |||||
| PRS-T2DM | 3768 | 1.42 (1.00–1.96) | 1.51 (1.04–2.05) | 0.016 | 0.048⁎ |
| Insulin resistance | |||||
| PRS-SCZ | 2344 | 1.16 (1.04–1.32) | 1.10 (0.99–1.22) | 0.089 | 0.089 |
a
Unadjusted analysis adjusted for 10 principal components only.
b
Samples for adjusted analysis included 3070 participants for psychotic outcomes and 1970 participants for insulin resistance outcome.
c
p-value corrected from adjusted analysis using Holm-Bonferroni method.
⁎
Evidence surpasses Holm-Bonferroni threshold.