Figure 5.

Aldh2 and Adh5 Act to Suppress Blood Formaldehyde Levels and Its DNA Adduct in Tissues

(A) Scheme of formaldehyde quantification in serum and as DNA adduct in tissues.

(B) Serum levels of formaldehyde (n = 43, 20, 51, 4, left to right). Boxes with lines indicate quartiles and median, and Tukey whiskers extend to 1.5 interquartile ranges. Two-tailed Mann-Whitney U test.

(C) Determination of the reduced genomic AA-deoxyguanine adduct N²-ethyl-deoxyguanosine from kidneys, liver, and brain (mean ± SEM; n = 4 per group).

(D) Determination of the reduced genomic formaldehyde-deoxyguanine adduct N²-methyl-deoxyguanosine from mouse kidneys, liver, and brain (mean ± SEM; n = 3–6 per group).

See also Figure S5.