Table 3.

ATTRwt Subgroup: Median Differences Between Treated and Untreated Patients With Diflunisal

ATTRwt (N = 53)	Untreated (N=37)		Treated (N=16)
	Baseline	Follow-up	Baseline	Follow-up	P
Echocardiography
LVEF, %	40	42	42	41	.32
GLS, %	−9.7	−8.5	−9.4	−9.3	.03
Apical/basal ratio	1.9	2.0	2.2	2.1	.63
IVSd, mm	15	17	16	17	.31
PWd, mm	16	17	16	16	.94
LAVI, mL/m2	42.3	46.6	43.7	42.7	.16
E/A	2.4	2.3	1.7	2.2	.46
Mean e′, cm/s	5	4	5	5	.09
E/e′	18	20	17	15	.10
Biomarkers
BNP, pg/mL	494	407	207	230	.56
Troponin I, ng/mL	0.10	0.12	0.07	0.07	.02
Creatinine, mg/dL	1.3	1.3	1.1	1.3	.41
eGFR, mL/min/1.73 m2	59.9	56.1	68.7	54.5	.21
TTR, mg/dL	22	19	24	33	.04

P values reflect change differences between follow-up and baseline for treated versus untreated patients. TTR: n=12 with complete baseline and follow-up TTR data.

Mean e′, average (septal and lateral) early mitral annular tissue velocity.