Skip to main content
. Author manuscript; available in PMC: 2020 Dec 24.
Published in final edited form as: Sci Signal. 2019 Feb 19;12(569):eaat8595. doi: 10.1126/scisignal.aat8595

Figure 6. SNAP25Δ3 mutant mice have impaired motor coordination and altered gait.

Figure 6.

A. Left panel: Mutant mice have normal locomotor behavior in the open chamber. Plot of distance traveled in five-minute intervals in a brightly illuminated open field for 15 week old littermate SNAP25Δ3 homozygotes (red line) (n=14 mice) and WT (blue line) (n= 15 mice). Middle and right panels: Total distance traveled (p=0.8088) and number of rearing movements (p=0.0796) made are plotted below for each genotype. B. Plot of latency to drop from an accelerating, rotating beam for 16 week old male WT (n=15 mice) and homozygotes SNAP25Δ3 (n=14 mice) in the rotarod paradigm. Animals were tested daily for three consecutive days. Age-matched littermate SNAP25Δ3 homozygotes had a significantly reduced latency to drop on the second and third day of testing compared to wild-type controls (**, p<0.01, ***, p<0.001, Student’s two-tailed t-test).