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Models of Smc5/6 Compaction Activity
DNA compaction by the Smc5/6 complex could be achieved by cooperative or non-cooperative mechanisms. In the cooperative scenario, DNA compaction would be the result of the association between several Smc5/6 complexes. Electrostatic interactions of single complexes with the DNA (wrapping) or an extrusion-like activity of the Smc5/6 complex could explain Smc5/6 compaction activity by non-cooperative mechanisms.
