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. 2020 Dec 8;5(50):32195–32202. doi: 10.1021/acsomega.0c03581

Figure 2.

Figure 2

Agonism of GPR120 with GW9508 prevented the ox-LDL-induced release of lactate dehydrogenase (LDH) in human aortic endothelial cells (HAECs). Cells were treated with ox-LDL (100 μg/mL) in the presence or absence of GW9508 (50 μM) for 24 h. (A) Molecular structure of GW9508. (B) Cells were treated with ox-LDL (25, 50, and 100 μg/mL) for 24 h. The release of LDH was assayed (*, P < 0.01 vs the vehicle group; # and ##, P < 0.01 and 0.001 vs the 25 μg/mL ox-LDL group); (C) Cells were treated with ox-LDL (100 μg/mL) in the presence or absence of GW9508 (50 μM) for 24 h. The release of LDH was measured. The release of LDH (%) = 100× (experimental LDH release-medium background)/(maximum LDH release control-medium background) (***, P < 0.0001 vs the vehicle group; ##, P < 0.001 vs the ox-LDL group).