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Effects of GW9508 in inhibiting cellular senescence in human aortic endothelial cells (HAECs). Cells were treated with ox-LDL (100 μg/mL) with or without GW9508 (50 μM) or the GPR120 antagonist AH7614 (1 μM) for 24 h. (A) SA-β-Gal activity; (B) mRNA of p53 and PAI-1; and (C) protein of p53 and PAI-1 (***, P < 0.0001 vs vehicle control; ##, P < 0.001 vs the ox-LDL group; and $$$, P < 0.0001 vs the ox-LDL + AH7614 group).
