TABLE 1.

Potential biomarkers were selected in plasma of COX-treated rats and normal rats.

No	TR (min)	Compound	Molecular formula	m/z obsd	m/z calcd	Error (ppm)	Ion mode	Treatment group vs. control group
1	0.93	Tryptophan	C11H12N2O2	227.0796	227.0796	0	+	↓**
2	0.92	Tyrosine	C9H11NO3	182.0817	182.0819	1.10	+	↓*
3	0.80	Glutamine	C5H10N2O3	169.0589	169.0587	–1.18	+	↓*
4	0.83	Pyroglutamine	C5H8N2O2	129.0664	129.0665	0.77	+	↓*
5	11.31	Alpha-ketoglutarate	C5H6O5	184.9852	184.9864	6.49	+	↓**
6	4.41	Sphingosine	C18H37NO2	300.2903	300.2902	–0.33	+	↑*
7	2.80	L-Octanoylcarnitine	C15H29NO4	288.2175	288.2169	–2.08	+	↓*
8	0.93	Phenylpyruvic acid	C9H8O3	165.0552	165.0547	–3.03	+	↑*
9	2.45	Prolylhydroxyproline	C10H16N2O4	251.1008	251.1014	2.39	+	↓*
10	5.37	LysoPC(20:4 (8Z,11Z,14Z,17Z)/0:0)	C28H50NO7P	566.3223	566.3218	–0.80	+	↓**
11	6.25	LysoPC(18:1 (11Z)/0:0)	C26H52NO7P	544.3379	544.3381	0.37	+	↑*
12	5.48	L-Palmitoyl carnitine	C23H45NO4	400.3427	400.3432	1.25	+	↓**
13	5.66	Alpha-linolenic acid	C18H30O2	279.2324	279.2314	–3.58	+	↑*
14	6.03	Tetradecanedioic acid	C14H26O4	297.1468	297.15	10.77	+	↑*
15	6.28	Trimethoprim	C14H18N4O3	291.1457	291.1437	–6.87	+	↑**
16	5.94	Cortolone-3-glucuronide	C27H42O11	565.2625	565.2661	6.37	+	↓**
17	2.53	Creatine	C4H9N3O2	130.0617	130.0623	4.61	–	↓*
18	5.28	LysoPE (0:0/24:6 (6Z,9Z,12Z,15Z,18Z,21Z))	C29H48NO7P	552.3090	552.3085	–0.91	–	↑*
19	7.69	Eicosapentaenoic acid	C20H30O2	301.2168	301.2188	6.64	–	↓*
20	5.93	12,13-Epoxy-9,15-octadecadienoic acid	C18H30O3	293.2117	293.2119	0.68	–	↑*
21	5.83	11,14,17-Eicosatrienoic acid	C20H34O2	305.2481	305.2500	6.22	–	↑**

The change trend is compared between the DOX group and the NS group. ↑ and ↓ represent up- and downregulation. *p < 0.05. **p < 0.01.