Table 8.

Summary of clinical studies with platelet-rich plasma or microneedling

YEAR	NO. OF PATIENT	AUTHOR	SPLIT-SCALP	INTERVENTION DONE	CONTROL PRESENT	ASSESSMENT	RESULTS	REMARKS
2006	20	Uebel et al13	YES	PRP ONLY	Yes	Manual Counting by Magnifying glass	15.1% better graft survival in grafts treated with PRP vs control.	PRP was compared for graft survival rate in receipients of Hair transplant surgery.
2013	100	Dhurat et al14	NO	MN and Mx vs Mx only.	MX only group present	By PH and 7 point Sx scale.	Dermaroller along with Minoxidil treated group was statistically superior to Minoxidil treated group in promoting hair growth.	Study only took Photographic assessment which may be subjective,PRP was not done.
2014	20	Gkini et al15	No	PRP only	No	HPT, DS, PH and aSX score	They concluded that PRP injections may have a positive therapeutic effect on male and female pattern hair loss without remarkable major side effects.	Beneficial effect of PRP were recorded but Microneedling was not done.
2014	11	Khatu et al16	No	PRP only	No	CE,PHHPT and patient’s SX.	PRP injection is a simple, cost effective and feasible treatment option for androgenic alopecia, with high overall patient satisfaction.	Trichoscopic analysis was not done and only PRP was done.
2015	4	Dhurat andMathapati,17	No	MN only	N.A	PH and patient SX scale	The authors of this study considered microneedling to be an effective, inexpensive and novel tool in the treatment of AGA warranting further study.	Dermoscopy was not done, only Microneedling was done. Patients were not on monotherapy.
2016	24	Alves and Grimalt18	Yes	PRP on split scalp	Yes	PH and PTG	Hair density, hair count increased significantly as compared to control side	Microneedling was not done, only PRP was done
2017	50	Kachhawa et al19	YES	PRP on split scalp	Yes	HPT, trichoscan software, patient SX.	Authors concluded that PRP injections have therapeutic effect on male pattern hair loss with no major side effects and high patient satisfaction overall.	PRP was injected on left side in all cases which could lead to bias.
2017	93	Jha et al20	NO	MX, MX and PRP, MX, PRP and MN.	Yes, MX only group	HPT, DS and PH	PRP with microneedling is better in comparison with PRP alone or minoxidil monotherapy in patients with AGA	The study in all treatment groups had minoxidil which can have synergistic effects.
2017	50	Shah et al21	NO	MX only and PRP+MN+MX	Yes, MX only group	Subjective assessment by patient and physician based evaluation on PH	There was a significant improvement (P < 0.05) in bothpatients’ assessment and investigator’s assessment in Group B (PRP+MN+Mx)as compared to Group A (Mx only) at the end of 6 months	No objective method was used to measure hair growth
2018	68	Kumar et al22	No	MX alone and MN with MX	Yes, MX only group	DS(hair count only), PH, patients self assessment	The study showed that the combination of MN and MX treatment was superior compared to topical MX alone with regard to increase in the hair count and patient SX, although the response achieved was not cosmetically significant	PRP was not done
2019	40	Verma et al23	NO	MX vs PRP	Yes MX only group	global photography, HPT, standardized hair growth questionnaire, patient satisfaction score	On Global photography: Better outcome in PRP group as compared to minoxidil group HPT negative in 75% in PRP compared to 42.8% in minoxidil group	Dermoscopic analysis was not done.