Fig. 3.

Humoral antibody response. The humoral response in the 1.0 mg dose group and 2.0 mg dose group was assessed for the ability to A) neutralize of live virus, (n = 18, 1.0 mg; n = 19, 2.0 mg). B) and binding to whole spike protein (S1 and S2) (n = 19, 1.0 mg; n = 19, 2.0 mg). End point titers for binding antibodies were calculated as the titer that exhibited an OD 3.0 SD above baseline, titers at baseline were set at 1 to normalize the post-baseline results. A response to live virus neutralization was a PRNT IC50 ≥ 10. In all graphs horizontal lines represent the Median and bars represent the Interquartile.