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. 2020 Dec 9;11:568423. doi: 10.3389/fphar.2020.568423

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Copyright © 2020 Xie, Lu, Yang, Zeng, Wei, Wang, Luo, Fang, Zeng and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of SAL on peripheral inflammation in SAMP8 mice. (A) Heatmap of 18 serum cytokine/chemokine levels, as detected by the Mouse High Sensitivity T Cell Magnetic Bead Panel. Quantitation of (B) IL-1α, (C) IL-6, (D) IL-12 and (E) IL-17A levels. (F) The spleen index was calculated as spleen weight (G)/mouse weight (G). (G) Flow cytometry results, including the proportions of CD3⁺CD4⁺ and CD3⁺CD8⁺ cells and the ratio of CD4⁺/CD8⁺ spleen lymphocytes. The bars represent the mean ± SE of each group (n = 3). ^# p < 0.05, and ^## p < 0.01 versus the R1-Ct group and *p < 0.05 and ***p < 0.001 versus the P8-Ct group.