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. 2020 Dec 9;10:607909. doi: 10.3389/fonc.2020.607909

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Copyright © 2020 Abancens, Bustos, Harvey, McBryan and Harvey

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sexual dimorphism in the correlation between KCNQ1:KCNE3 and CRC patient relapse-free survival. Sex-differentiated analysis of human primary CRC tumor patient databases (accession number: GSE39582) showed a positive correlation between KCNQ1 and KCNE3 expression and disease-free survival in female patients only with no correlation observed in male patients. Survival analysis carried out using the R2 data visualisation platform from the Amsterdam Medical Centre R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl) publically available datasets gse39582. Median gene expression values was used to separate between high and low expression. P-values were calculated based on a logrank test. Sufficient data was not available to calculate overall survival.