Table 1.

Definitions of high-risk prostate cancer

Classification system	PSA (ng/ml)	Grade group	Clinical stage
D’Amico[11]	>20	4-5	T2c
AUA/ASTRO/SUO[2]	≥20	4-5	≥T3
EAU (localized)[3]	>20	4-5	T2c
EAU (locally advanced)[3]	Any	Any	T3-4 or N1
NCCN (high)[12]	>20	4-5	T3a
NCCN (very high)[12]	Any	Primary 5 or >4 cores of 4-5	T3b-4

PSA=Prostate-specific antigen, AUA=American Urological Association, ASTRO=American Society for Radiation Oncology, SUO=Society of Urologic Oncology, EAU=European Urology Association, NCCN=National Comprehensive Cancer Network