Table 2.
Stratified diagnosis criteria of SARS-CoV-2 infection in patients with HMs
| Case category | Criteria for diagnosis |
| Surveillancea | 1. The patient presents with systemic or respiratory signs and symptoms, such as fever, fatigue, nausea, vomiting, and diarrhea. 2. The patient had a close contact with clinically suspected or confirmed COVID-19 cases. |
| Suspectedb | 1. History of exposure: The patient had a living history or travel history in and around areas with high COVID-19 prevalence or stayed in the community with suspected COVID-19 cases. The patient had close contact with individuals who had been to areas with high COVID-19 prevalence or the community with suspected COVID-19 symptoms. The patient was from one of the COVID-19 clusters. The patient had a contact history with confirmed COVID-19 patients. 2. Clinical manifestations: The patient presents with fever or respiratory symptoms like non-productive cough, dyspnea, and chest tightness. The imaging test of the patient shows pneumonia features with multiple spot shadows and interstitial changes. It could progress into multiple infiltration shadows on bilateral lung and pulmonary consolidation in severe cases; however, pleural effusion is rare. The total leukocyte count, granulocyte count, and (or) lymphocyte count could be reduced. When there are no definite or convincing etiologies to explain the clinical manifestations thoroughly. |
| Confirmedc | 1. Positive nucleic acid detection of the SARS-CoV-2 from the samples (respiratory tract secretion, blood, etc.) by RT-PCR; 2. Sequencing of the SARS-CoV-2 viral genomes from samples of the respiratory tract or blood; 3. Both IgM and IgG serological results of SARS-CoV-2 test positive. |
Cases that are consistent with one of the diagnostic items should be kept under clinical observation.
Suspected cases refer to any individuals with a confirmed history of exposure, accompanied by two of the clinical manifestations.
Cases that are compatible with each of the diagnostic items can be diagnosed as a confirmed case of COVID-19. COVID-19, coronavirus disease 2019; HMs, hematological malignancies; Ig, immunoglobulin; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; RT-PCR, real-time polymerase chain reaction. Stratified diagnosis criteria refer to Liang et al. (2020), China National Health Commission (2020), and Subspecialty Group of Hematology and Oncology, Society of Pediatrics of Hubei (2020)