Table 4.

Principal causative factors of fever in patients with hematological cancers

Causative factor	Example
Infectious fever	Viral infections, including SARS-CoV-2, CMV, and RSV Fungal infections Bacterial infections Others, such as mycoplasma
Treatment-associated fever	Chemotherapeutics, such as high-dose MTX, L-ASP, and Ara-C aGVHD after HSCT CRS induced by CAR-T therapy Others
Oncological fever	NHL: body temperature >38 °C accompanied by weight loss or (and) night sweats HL: patients could present with unknown persistent fever; 1/6 patients could develop Pel Ebstein fever Others

aGVHD, acute graft versus host reaction; Ara-C, cytarabine; CAR-T, chimeric antigen receptor T cell; CMV, cytomegalovirus; CRS, cytokine release syndrome; HL, Hodgkin lymphoma; HSCT, hematopoietic stem cell transplantation; L-ASP, L-asparaginase; MTX, methotrexate; NHL, non-Hodgkin lymphoma; RSV, respiratory syncytial virus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2