Table 3.

Pathways with case-control discrepancy in MS MWAS.

GO term	Set size	P-value	Name
GO:0009279	572	1.5 × 10−7	cell outer membrane
GO:0005829	408	1.5 × 10−7	cytosol
GO:0015562	228	1.6 × 10−7	efflux transmembrane transporter activity
GO:0030288	176	1.6 × 10−7	outer membrane-bounded periplasmic space
GO:0042802	102	1.7 × 10−7	identical protein binding
GO:0006974	54	1.8 × 10−7	cellular response to DNA damage stimulus
GO:0000272	85	2.6 × 10−6	polysaccharide catabolic process
GO:0042597	190	6.2 × 10−6	periplasmic space
GO:0006355	4053	7.8 × 10−6	regulation of transcription, DNA-templated
GO:0005886	9545	9.4 × 10−6	plasma membrane
GO:0004853	69	2.1 × 10−5	uroporphyrinogen decarboxylase activity
GO:0008422	177	3.5 × 10−5	beta-glucosidase activity
GO:0003677	20242	3.9 × 10−5	DNA binding
KEGG pathway	Set size	P-value	Name
ko00540	318	2.1 × 10−7	Lipopolysaccharide biosynthesis
ko00790	794	1.5 × 10−4	Folate biosynthesis

GO, gene ontology; MS, multiple sclerosis; MWAS, metagenome-wide association study.