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. 2020 Dec 11;10:603623. doi: 10.3389/fcimb.2020.603623

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Copyright © 2020 Wall, Brownridge, Laing, Terra, Mlozowa, Denis, Nyirenda, Allain, Ramos-Sevillano, Carrol, Collins, Gordon, Lalloo, Wren, Beynon, Heyderman and Brown

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Highly abundant CSF proteins in pneumococcal meningitis are directly involved in the host-pathogen interaction and demonstrate evidence of blood-brain barrier breakdown. Venn diagram showing overlap between the uniport peptide hits from the proteome of patients with PM and two previously published proteomes of normal CSF (A). Bubble plot showing breakdown of proteins found in the subset of proteins unique to PM n = 130 from Figure 1 (B). Green, cellular functional proteins; blue, proteins synthesized by white and plasma cells; purple, complement and clotting cascades; orange, pro-inflammatory proteins.