Table 4.

Abundance and function of pneumococcal proteins in the CSF of patients with PM, in order of abundance.

	Protein	Function	Estimated abundance (units)		Protein	Function	Estimated abundance (units)
1	Elongation factor Tu	Multi-function	9.20E+05	11	Thioredoxin	Stress response	4.46E+04
2	Chaperone protein DnaK	Protein folding	2.52E+05	12	Enolase	Carbohydrate degradation	4.05E+04
3	Ribosomal proteins (n=8)	Ribosome	1.80E+05	13	Acyl carrier protein	Lipid metabolism	3.83E+04
4	Pyruvate oxidase	Metabolism	1.60E+05	14	Endo- Peptidase O	Virulence	2.16E+04
5	Ketol-acid reductoisomerase	Metabolism	1.36E+05	15	ABC transporter GalT1	Metabolism	1.52E+04
6	Glyceraldehyde-3-phosphate dehydrogenase	Metabolism, immuno-stimulant	1.09E+05	16	Phosphoglycerate kinase	Metabolism	1.30E+04
7	Histone-like DNA-binding protein	DNA stabilization	1.08E+05	17	Pyruvate kinase	Metabolism	2.96E+03
8	Manganese ABC transporter substrate-binding lipoprotein	Surface antigen	1.03E+05	18	Uncharacterized protein	Unknown	2.54E+03
9	Glutamate dehydrogenase	Metabolism	4.78E+04	19	General stress protein GSP-781	Stress response	2.23E+03
10	Elongation factor G	Translation and collagen binding	4.64E+04	20	Surface protein pspA	Virulence and surface antigen	2.8E+03