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. 2020 Dec 11;8:607906. doi: 10.3389/fcell.2020.607906

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Copyright © 2020 Zhang, Jiang, Yang, Sun, Liu, Shi, Hu, Pan, Liu, Jin and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of SERPINE2 as a novel downstream gene regulated by BAP31 in HCC cells. (A) Identification of the genes regulated by BAP31 in HCC cells using RNA-Seq analysis. A heat map was constructed based on the genes differentially expressed between the control and BAP31-knockdown cells. (B) Comparative intersection analysis of differentially expressed genes in the BAP31-knockdown and control Hep3b and MHCC97h cells. (C) qRT-PCR analysis of SERPINE2 expression in the BAP31-knockdown and control HCC cells. (D) Lysates of HCC cells expressing the indicated proteins were immunoprecipitated with anti-BAP31, anti-SERPINE2, or mouse IgG isotype antibody, and the immunoprecipitates were probed with the indicated antibodies. (E,F) Colocalization of BAP31 (green) with SERPINE2 (red) in wild-type (E) and BAP31-overexpression and -knockdown and control (F) HCC cells according to confocal microscopy. BAP31, B-cell receptor-associated protein 31; HCC, hepatocellular carcinoma; SERPINE2, serpin family E member 2. **p < 0.01.