Table 4.

Comparative MRI metrics of patients with or without thalamic lesions

	With thalamic lesions	Without thalamic lesions	p-value*
N	38	52
Gender (M/F)	11/27	11/41	0.396
Age, years	44.4 (9.4)	41.2 (8.7)	0.107
Disease duration, years	10 (8.9)	8.8 (9.4)	0.312
EDSS score, median (range)	3.5 (8)	2 (7)	0.021
SDMT, Z-score	−0.4 (1.6)	0.2 (1.4)	0.064
RRMS:SPMS	20:18	41:11	0.009
Leukocortical lesion volume	1512 ± 2214	318 ± 605	0.054
Intracortical lesion volume	6.9 ± 15.3	300 ± 542	0.002
Subpial lesion volume	711 ± 864	296 ± 542	0.002
White matter lesion volume	6228 ± 10325	3848 ± 5487	0.191
Thalamus volume	4349 ± 792	4583 ± 931	0.198

All values are reported as mean (SD);

^*for comparisons between subjects with and without thalamic lesions