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. 2020 Dec 11;11:569760. doi: 10.3389/fimmu.2020.569760

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Copyright © 2020 Canedo-Marroquín, Saavedra, Andrade, Berrios, Rodríguez-Guilarte, Opazo, Riedel and Kalergis

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune response against SARS-CoV-2. Cellular infiltration and Cytokines storm upon the infection of SARS-CoV-2. After SARS-CoV-2 recognition and replication in type II pneumocytes, peripheral blood cells are recruitment to alveoli, with a release of cytokines and chemokines (IL-2, IL-7, G-SCF, IP-10, MCP-1, MIP-1A, and TNFα), allowing infiltration into the lung of granulocytes and mononuclear cells as monocytes, lymphocytes, and NK cells. Lungs-infiltrated cells are also involving in cytokines storm.