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. 2020 Dec 11;8:609297. doi: 10.3389/fbioe.2020.609297

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Copyright © 2020 Liu and Segura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Macrophage origin: from the time Metchnikoff discovered macrophages (Metchnikoff, 1883), to the establishment of the reticuloendothelial system (Aschoff, 1924) and mononuclear phagocyte system (Langevoort, 1970; van Furth et al., 1972a), to the current consensus of macrophage heterogeneity (Lichanska and Hume, 2000; Gordon and Taylor, 2005; Chorro et al., 2009; Wynn et al., 2013; Epelman et al., 2014). (B) Macrophage-biomaterial response: a PubMed search with key words “macrophage” and “biomaterial” reveals the increasing popularity of this topic over time and our constantly evolving knowledge (Homsy, 1970; Anderson and Miller, 1984; Badylak et al., 2008; Madden et al., 2010; Sadtler et al., 2016).