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. 2020 Dec 11;8:609297. doi: 10.3389/fbioe.2020.609297

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Copyright © 2020 Liu and Segura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macrophages are central players during the host response to biomaterials. They closely interact with other cells and persist at the material-body interface throughout the inflammation and regeneration stages. TGF-β, transforming growth factor-beta; PDGF, platelet-derived growth factor; CXCL4, chemokine (C-X-C motif) ligand 4; LTB4, leukotriene B4; IL, interleukins; PMNs, polymorphonuclear leukocytes; TNF-α, tumor necrosis factor-alpha; M-CSF, macrophage-colony stimulating factor; GM-CSF, granulocyte macrophage colony stimulating factor; MCP-1, monocyte chemoattractant protein-1; VEGF, vascular endothelial growth factor; FGF, fibroblast growth factor. The list of molecules is not comprehensive.