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. 2020 Dec 11;11:577467. doi: 10.3389/fphar.2020.577467

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Copyright © 2020 Elfiky

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sequence comparison (A) Part of the multiple sequence alignment for the spike protein of all of the currently reported human coronaviruses strains (NL63, 229E, OC43, HKU1, MERS-CoV, SARS-CoV, and SARS-CoV-2). The alignment is made using the Clustal Omega web server and is displayed by ESpript 3 software. The yellow highlighted residues are conserved among the seven HCoVs. GRP78 recognition site (C480-C488 in SARS-CoV-2) is marked in red (B) Pairwise sequence alignment between Pep42 from one side and NL63, 229E, OC43, HKU1, and SARS-CoV-2 from the other side. Red and yellow residues are identical and similar residues, respectively.