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. 2020 Dec 11;11:600026. doi: 10.3389/fneur.2020.600026

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Copyright © 2020 Mutti, Bernabè, Barozzi, Ciliento, Trippi, Pedrazzi, Azzi and Parrino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dynamics of epileptiform discharges during NREM and REM sleep in a patient with SHE. (A) Bursts of generalized epileptiform discharges enhancing cyclic alternating pattern (CAP) fluctuations during stage N2 in a patient with SHE. Red boxes highlight CAP cycles. Transient heart rate fluctuations consistent with sleep instability. (B) REM sleep constrains epileptic phenomena and may provide information on the localization of seizure onset zone (left focal fronto-temporal spikes and sharp-waves). EEG sensitivity 44.5 mV/cm; Milo+, chin electromyography; BEAT, heart frequency; SpO2+, oxygen saturation.