Table 2.
The list of known or novel non-canonical ALK gene fusions identified in the NSCLC patient cohort.
| ALK Fusion Partner | ALK Fusion Group | Fusion Site | FISH | IHC (Ventana) | |
|---|---|---|---|---|---|
| Known ALK fusions | GALNT14 | Pure non-canonical ALK fusions | GALNT14-ALK (exon1:exon19) | + | + |
| HIP1 | Pure non-canonical ALK fusions | HIP1-ALK (exon19:exon20) | + | + | |
| HIP1 | Complex ALK fusions | HIP1-ALK (exon1:exon16) | NA* | + | |
| HIP1 | Pure non-canonical ALK fusions | HIP1-ALK (exon19:exon19) | NA | + | |
| KIF5B | Pure non-canonical ALK fusions | KIF5B-ALK (exon17:exon20) | + | NA | |
| SETD2 | Pure non-canonical ALK fusions | SETD2-ALK (exon1:exon20) | NA | + | |
| KLC1 | Pure non-canonical ALK fusions | KLC1-ALK (exon9:exon20) | + | + | |
| BIRC6 | Complex ALK fusions | BIRC6-ALK (exon43:exon19) | + | + | |
| LOC728730 | Complex ALK fusions | LOC728730-ALK (exon5:exon20) | NA | + | |
| CRIM1 | Complex ALK fusions | CRIM1-ALK (exon2:exon20) | + | + | |
| CLIP4 | Complex ALK fusions | CLIP4-ALK (exon1:exon20) | + | NA | |
| PPP1R21 | Complex ALK fusions | PPP1R21-ALK (exon8:exon20) | + | + | |
| Novel ALK fusions | DMD | Pure non-canonical ALK fusions | DMD-ALK (exon55:exon20) | + | + |
| ALK | Pure non-canonical ALK fusions | ALK-ALK (intron1:intron19) | + | + | |
| TMEM178A | Pure non-canonical ALK fusions | TMEM178A-ALK (exon1:exon20) | NA | + | |
| SYNE1 | Pure non-canonical ALK fusions | SYNE1-ALK (exon63:exon20) | NA | + | |
| ZC3H8 | Pure non-canonical ALK fusions | ZC3H8-ALK (exon8:exon20) | + | NA | |
| ADI1 | Pure non-canonical ALK fusions | ADI1-ALK (exon2:exon20) | + | NA | |
| AFF3 | Pure non-canonical ALK fusions | AFF3-ALK (exon12:exon20) | NA | + | |
| PRKCE | Complex ALK fusions | PRKCE-ALK (exon10:exon20) | NA | + | |
| CELF4 | Complex ALK fusions | CELF4-ALK (exon2:exon20) | + | NA | |
| MALL | Complex ALK fusions | MALL-ALK (exon1:exon20) | + | + | |
| SBF2 | Complex ALK fusions | SBF2-ALK (exon1:exon18) | + | NA | |
| PSMA8 | Complex ALK fusions | PSMA8-ALK (exon2:exon18) | + | + | |
| KCNG3 | Complex ALK fusions | KCNG3-ALK (exon1:exon20) | + | NA | |
| PXDN | Complex ALK fusions | PXDN-ALK (exon1:exon20) | + | NA | |
| RNF10 | Pure non-canonical ALK fusions | RNF10-ALK (exon1:exon19) | NA | + |
*NA, Results not available due to lack of testing information.