Table 1.
Baseline Characteristics of Patients with Diffuse- and Localized-type Esophageal Eosinophilia.
| Diffuse EE | Localized EE | p value | ||||
|---|---|---|---|---|---|---|
| n | 52 | 29 | - | |||
| median age (range, years) | 48.5 (18-74) | 49 (33-77) | ns | |||
| gender | ||||||
| men (%) | 41 (78.8) | 28 (96.6)* | 0.0476* | |||
| allergic diseases (%) | ||||||
| bronchial asthma | 7 (13.5) | 0 | 0.0460* | |||
| allergic rhinitis | 20 (57.1) | 11 (37.9) | ns | |||
| atopic dermatitis | 3 (5.7) | 2 (6.9) | ns | |||
| any | 26 (50.0) | 13 (44.8) | ns | |||
| diagnostic opportunities | ||||||
| GI screening (%) | 43 (82.7) | 23 (79.3) | ns | |||
| GI symptoms (%) | 3 (5.8) | 4 (13.8) | ns | |||
| others (%) | 6 (11.5) | 2 (6.9) | ns | |||
| any upper GI symptoms | 19 (36.5) | 7(24.1) | ns | |||
| dysphagia (%) | 11 (21.2) | 2 (6.9) | ns | |||
| food impaction (%) | 6 (11.5) | 0 (0) | ns | |||
| heartburn (%) | 16 (30.7) | 7 (24.1) | ns | |||
| others (%) | 4 (7.7) | 1 (3.4) | ns | |||
| PPI use at the first diagnosis(%) | 2 (3.8) | 1 (3.4) | ns | |||
| History of esophageal dilatation | 0 | 0 | ns | |||
| prevalence of endoscopic findings | ||||||
| rings (%) | 36 (69.2) | 8 (27.6)* | 0.0004* | |||
| furrows (%) | 42 (80.7) | 27 (93.1) | ns | |||
| exudate (%) | 40 (76.9) | 23 (79.3) | ns | |||
| edema (decreased vascularity) (%) | 52 (100) | 29 (100) | ns | |||
| stricture (%) | 1 (1.9) | 0 (0) | ns | |||
| endoscopic score (median, range) | ||||||
| rings | 1 (0-2) | 0 (0-1) | 0.0001** | |||
| furrows | 2 (0-2) | 2 (0-2) | ns | |||
| exudate | 1 (0-1) | 1 (0-1) | ns | |||
| edema(decreased vascularity) | 1 (1-1) | 1 (1-1) | ns | |||
| stricture | 0 (0-1) | 0 (0-0) | ns | |||
| total | 4 (1-6) | 3 (2-5) | 0.018** | |||
| erosive esophagitis(%) | 6 (11.5) | 1 (3.4) | ns | |||
| hiatal hernia | 7/42*** (16.7) | 4/22*** (18.2) | ns | |||
| number of esophageal eosinophilia(/HPF) (median, range) | ||||||
| abnormal-appearing area | 62 (17-258) | 46 (16-162) | ns | |||
| normal-appearing mucosa | - | 0 (0-12) | - |
*Fisher’s exact probability test.
**Wilcoxon’s rank sum test.
***Ten diffuse EE and seven localized EE patients who were assessed using nasal endoscopy with a small caliber were excluded.
EE: esophageal eosinophilia