Table 4.
Endoscopic and Histological Findings at the First and Last Endoscopy Session in Asymptomatic EE with Long-term Follow up of More than Three Years.
| Diffuse EE | Localized EE | ||||||
|---|---|---|---|---|---|---|---|
| first EGD | last EGD | p value | first EGD | last EGD | p value | ||
| n | 14 | 14 | - | 7 | 7 | - | |
| mean age at the first diagnosis (range, years) | 52 (37-74) | - | - | 52 (44-74) | - | - | |
| mean number of follow-up endoscopy | 5 (3-7) | 4 (3-6) | |||||
| median follow up period (range, months) | 61 (36-82) | 49 (39-72) | |||||
| progression to symptomatic EE | - | 0 | - | - | 0 | - | |
| PPI users (%) | 1 (7.1) | 5(35.7) | ns | 0 | 1 (14.3) | ns | |
| prevalence of endoscopic findings | |||||||
| rings (%) | 8 (57.1) | 8 (57.1) | ns | 2 (28.6) | 1 (14.3) | ns | |
| furrows (%) | 10 (71.4) | 7 (50.0) | ns | 6 (85.7) | 1 (14.3) | 0.0291* | |
| exudate (%) | 12 (85.6) | 8 (57.1) | ns | 3 (42.9) | 1 (14.3) | ns | |
| edema (decreased vascularity) (%) | 14 (100) | 12 (85.7) | ns | 7 (100) | 6 (85.7) | ns | |
| stricture (%) | 0 (100) | 0 (100) | ns | 0 | 0 | ns | |
| endoscopic score (median, range) | |||||||
| rings | 1 (0-2) | 1 (0-2) | ns | 0 (0-1) | 0 (0-1) | ns | |
| furrows | 1.5 (0-2) | 0.5 (0.2) | ns | 2 (0-2) | 0 (0-2) | ns | |
| exudate | 1 (0-2) | 1 (0-1) | 0.0313** | 0 (0-1) | 0 (0-1) | ns | |
| edema (decreased vascularity) | 1 (1-1) | 1 (0-1) | ns | 1 (1-1) | 0 (0-1) | ns | |
| stricture | 0 (0-0) | 0 (0-0) | ns | 0 (0-0) | 0 (0-0) | ns | |
| total score | 4 (1-7) | 3 (0-7) | ns | 3 (2-5) | 1 (0-4) | 0.0156** | |
| number of esophageal eosinophilia (/HPF)(median, range) | 57.5 (18-118) | 76 (0-110)*** | ns | 54 (33-162) | 10 (0-46)*** | ns | |
*Fisher’s exact probability test.
**Wilcoxon’s signed rank test.
***Esophageal biopsies were not obtained from 5 of 14 diffuse and 2 of 7 localized patients in the last endoscopy.
EE: esophageal eosinophilia, EGD: esophagogastroduodenoscopy, PPI: proton pump inhibitor